In addition, fomepizole treatment, unlike NAC, prevented APAP-induced kidney damage and promoted hepatic regeneration in mice. In animal studies, fomepizole effectively prevented APAP-induced liver injury by inhibiting Cyp2E1 when treated early, and by inhibiting c-jun N-terminal kinase (JNK) and oxidant stress when treated after the metabolism phase. Fomepizole (4-methylpyrazole), a clinically approved antidote against methanol and ethylene glycol poisoning, recently emerged as a promising candidate. Thus, additional antidotes with an extended therapeutic window may be needed for these patients. However, for late-presenting patients or after ingestion of very large overdoses, the efficacy of NAC is diminished. The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. Garlic Cyanide poisoning smells like.Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure.

Antidote for Heparin overdose? Protamine sulfate What is the treatment of choice in Iron overdose? Deferoxamine, deferasirox What are some common antidotes for Lead poisoning? EDTA, dimercaperol, succimer, penicillamine Mercury, arsenic gold Dimercaprol, Succimer What antidote is used to treat Methanol or Ethylene glycol toxicity? Fomepizole > ethanol, dialysis What is the treatment for Methemoglobinemia? Methylene blue, vitamin C What is the antidote for Opioid overdose? Naloxone What is the antidote for salicylate overdose? NaHCO3 (alkalinize urine), dialysis What is the antidote for acute TCA poisoning? NaHCO3 (plasma alkalinization) What is the antidote of choice for overdose of tPA/streptokinase/urokinase? Aminocaproic acid What is the antidote for Warfarin toxicity? Fresh frozen plasma (immediate), Vitamin K (Delayed effect) Arsenic poisoning smells like.

Antidote paracetamol overdose